The RAS superfamily of GTPases includes five major subfamilies of monomeric guanine nucleotide binding proteins (RAS, RHO, RAB, RAN and ARF), which possess GDP/GTP-binding and intrinsic GTPase ...
The RAS family commonly drives the growth and survival of human cancers. Mutations in KRAS, NRAS, and HRAS occur in approximately 20% of all human cancers, including solid tumors, such as pancreatic, ...
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