pharmaphorum

Pfizer's seeks silver lining in failed C. diff vaccine trial

Pfizer's vaccine for Clostridium difficile (C. diff) looks like it may join a growing list of candidates that have been shelved or delayed, after the shot failed to meet its primary objective in a ...
pharmaphorum

Nestle bids to take control of Seres’ C diff drug Vowst

Swiss food giant Nestlé has said it wants to take full ownership of Seres Therapeutics’ Vowst microbiome therapy for Clostridiodes difficile infections (CDI), upgrading its current co-marketing ...
eLife

REM sleep prefrontal high-frequency oscillation chains mediate distinct cortical – hippocampal reactivation patterns compared to NREM sleep

REM (rapid eye movement) and non-REM (NREM) sleep stages contribute to systems memory consolidation in hippocampal-cortical circuits. However, the physiological mechanisms underlying REM memory ...
eLife

Distinct allosteric remodeling of HIV-1 Env dynamics on virions by gp41-directed antibodies reveals two modes of neutralization

HIV-1 envelope glycoprotein (Env), a gp120–gp41 trimer, undergoes coordinated conformational changes that drive membrane fusion and allow immune evasion by transiently concealing ...
GitHub

Ref-Diff: Zero-shot Referring Image Segmentation with Generative Models

Zero-shot referring image segmentation (RIS) is a challenging task that involves identifying an instance segmentation mask based on referring descriptions, without having been trained on such paired ...
IEEE

10.3 A 7GHz Digital PLL with Cascaded Fractional Divider and Pseudo-Differential DTC Achieving -62.1dBc Fractional Spur and 143.7fs Integrated Jitter

Abstract: Modern wireless transceivers and FMCW radar systems are demanding stringent specifications on PLL integrated jitter and spur performance for lower EVM and higher position accuracy. To ...