eLife

Molidustat Targets a Synthetic Lethal Vulnerability in APC-Mutant Colorectal Cancer through GSTP1 and PHD2 Co-Inhibition

This important paper substantially advances our understanding of how Molidustat may work, beyond its canonical role, by identifying its therapeutic targets in cancer. This study presents a compelling ...

Train-to-Test scaling explained: How to optimize your end-to-end AI compute budget for inference

AI reasoning does not necessarily require spending huge amounts on frontier models. Instead, smaller models can yield ...
Hackaday

Python Comes To The Arduino Uno Q

MicroPython is a well-known and easy-to-use way to program microcontrollers in Python. If you’re using an Arduino Uno Q, ...
eLife

Serotonergic modulation of motor subspace dynamics drives a sleep-independent quiescent state

The dorsal raphe nucleus (DRN) serotonergic (5-HT) system has been implicated in regulating sleep and motor control; however, its specific role remains controversial. In this study, we found that ...

Databricks research shows multi-step agents consistently outperform single-turn RAG when answers span databases and documents

Data teams building AI agents keep running into the same failure mode. Questions that require joining structured data with ...
Nature

Digital health: Smartphone-based monitoring of multiple sclerosis using Floodlight

In order to improve care for people with multiple sclerosis (MS), we need to understand more about their disease. The way we measure the impact of MS on daily life has remained relatively unchanged ...
Beirut Time

Mapping convergent regulators of melanoma drug resistance by PerturbFate

A375, HEK293T, Sk-Mel-3 and Sk-Mel-24 cell lines were obtained from the American Type Culture Collection. A375 and HEK293T cells were maintained in ...