eLife

Distinct allosteric remodeling of HIV-1 Env dynamics on virions by gp41-directed antibodies reveals two modes of neutralization

HIV-1 envelope glycoprotein (Env), a gp120–gp41 trimer, undergoes coordinated conformational changes that drive membrane fusion and allow immune evasion by transiently concealing ...
eLife

REM sleep prefrontal high-frequency oscillation chains mediate distinct cortical – hippocampal reactivation patterns compared to NREM sleep

REM (rapid eye movement) and non-REM (NREM) sleep stages contribute to systems memory consolidation in hippocampal-cortical circuits. However, the physiological mechanisms underlying REM memory ...
Harvard Business Review

What Is Disruptive Innovation?

Twenty years after the introduction of the theory, we revisit what it does—and doesn’t—explain. by Clayton M. Christensen, Michael E. Raynor and Rory McDonald Please enjoy this HBR Classic. Clayton M.
Scientific Research Publishing

Construction of a Risk Prediction Model for Diabetic Nephropathy Based on the Urinary Microalbumin-to-Creatinine Ratio and Blood Markers ()

Based on this, this study retrospectively analyzes the clinical testing data of patients with diabetic nephropathy and those with simple diabetes mellitus to investigate the predictive value of ...